Holders Bayern Munich started with reserve goalkeeper Alexander Nuebel for their Champions League last-16 second leg against Lazio on Wednesday, with club captain Manuel Neuer sidelined by a cold. Nuebel was given only his third start this season, with Bayern holding a 4-1 lead from the first leg. The club world champions, who are bidding to reach the quarter-finals for the ninth time in 10 years, were also missing winger Kingsley Coman, who failed to recover from a leg injury. Lazio coach Simone Inzaghi pulled a surprise with top-scorer Ciro Immobile rested and Vedat Muriqi starting up front alongside Joaquin Correa. In midfield, Argentine Gonzalo Escalante started ahead of Brazilian Lucas Leiva while Adam Mursuic was deployed in a back three. Algeria international Mohamed Fares and Italy's Manuel Lazzari started as the wing-backs. Bayern Munich (4-2-3-1) Alexander Nuebel; Benjamin Pavard, Jerome Boateng, David Alaba, Lucas Hernandez; Leon Goretzka, Joshua Kimmich; Leroy Sane, Thomas Mueller (capt), Serge Gnabry; Robert Lewandowski Coach: Hansi Flick (GER) Lazio (3-5-2) Pepe Reina; Adam Marusic, Francesco Acerbi, Stefan Radu; Manuel Lazzari, Sergej Milinkovic-Savic (capt), Gonzalo Escalante, Luis Alberto, Mohamed Fares; Joaquin Correa, Vedat Muriqi Coach: Simone Inzaghi (ITA) Referee: Istvan Kovacs (ROU) ryj/jc