We will move the following business and economics stories: + Singapore gets shot in the arm from global drug demand + The pandemic made 2020 a wild year for Wall Street + Tech stars quit Silicon Valley as politics, pandemic weigh + Takeda chief urges transparency in virus vaccine rollout + Long way before Africa's single market moves at full steam Singapore-economy-pharmaceutical-health-virus,FOCUS SINGAPORE Scientists in protective clothing work in a high-tech laboratory at a pharmaceutical plant in Singapore, whose coronavirus-hit economy has received a shot in the arm from robust global drug demand. 650 words by Martin Abbugao. Picture. Video Year2020-US-stocks-markets,POINTS NEW YORK Quincy Krosby, chief market strategist at Prudential Financial, does not hold back in describing 2020 on Wall Street: "a year of extreme extremes." 750 words by Daniel Hoffman. File picture US-IT-politics-SiliconValley SAN FRANCISCO Silicon Valley is seeing departures of some of its high-profile stars as a pandemic-linked shift to remote work and political polarization have dulled the allure of the key tech industry hub. 800 words by Glenn Chapman. File picture Health-virus-vaccine-Japan-Takeda,INTERVIEW TOKYO Pharmaceutical firms must be "very transparent" about the risks and benefits of vaccines to help efforts to eradicate the coronavirus pandemic, the head of Asia's largest drugmaker says. 700 words. Picture Africa-AU-trade-politics JOHANNESBURG Touted as the world's largest single market in terms of the number of member nations, Africa's ambitious blueprint for free trade kicks into gear on January 1, bringing together more than 50 economies from Algeria to South Africa. 600 words. Video afp