Results from day four of the US Open tennis championship at Flushing Meadows on Thursday (x-denotes seed): Men's singles 2nd rd Matteo Berrettini (ITA x6) bt Ugo Humbert (FRA) 6-4, 6-4, 7-6 (8/6) Casper Ruud (NOR x30) bt Emil Ruusuvuori (FIN) 6-4, 6-3, 3-2 retired Salvatore Caruso (ITA) bt Ernesto Escobedo (USA) 3-6, 6-4, 6-3, 6-4 Andrey Rublev (RUS x10) bt Gregoire Barrere (FRA) 6-2, 6-4, 7-6 (7/4) Jeffrey Wolf (USA) bt Roberto Carballes (ESP) 6-2, 6-4, 6-3 Roberto Bautista (ESP x8) bt Miomir Kecmanovic (SRB) 6-3, 3-6, 6-3, 6-4 Vasek Pospisil (CAN) bt Milos Raonic (CAN x25) 6-7 (1/7), 6-3, 7-6 (7/4), 6-3 Alex De Minaur (AUS x21) bt Richard Gasquet (FRA) 6-4, 6-3, 6-7 (6/8), 7-5 Karen Khachanov (RUS x11) bt Andrey Kuznetsov (RUS) 6-3, 6-4, 6-1 Marin Cilic (CRO x31) bt Norbert Gombos (SVK) 6-3, 1-6, 7-6 (7/2), 7-5 Dominic Thiem (AUT x2) bt Sumit Nagal (IND) 6-3, 6-3, 6-2 Women's singles 2nd rd Donna Vekic (CRO x18) bt Patricia Tig (ROU) 6-2, 6-1 Tsvetana Pironkova (BUL) bt Garbine Muguruza (ESP x10) 7-5, 6-3 Maria Sakkari (GRE x15) bt Bernarda Pera (USA) 2-6, 6-3, 6-2 Amanda Anisimova (USA x22) bt Katrina Scott (USA) 4-6, 6-4, 6-1 Karolina Muchova (CZE x20) bt Anna Kalinskaya (RUS) 6-3, 7-6 (7/4) Sorana Cirstea (ROU) bt Johanna Konta (GBR x9) 2-6, 7-6 (7/5), 6-4 Ons Jabeur (TUN x27) bt Kaia Kanepi (EST) 7-6 (10/8), 6-0 Sofia Kenin (USA x2) bt Leylah Fernandez (CAN) 6-4, 6-3 afp